TMG Betaine

Trimethylglycine (TMG)

Key Findings on TMG

  • TMG or Betaine found in fruits and coffee is a Glycine amino-acid that is attached to 3 methyl groups (hence the name begins with”tri”). 
  • TMG is synthesised in the liver from Choline, in a 2 steps reaction process. Further, in a cascade of processes, TMG helps converts homocysteine into Methionine.
  • Methionine further enhances the production of:
    • Glutathione – Important for immune responses
    • Serotonin – the deficiency of serotonin leads to various emotional disorders; and
    • Melatonin – our sleep hormone
  • Methionine also further helps the liver detox harmful toxic metals such as Mercury. Lipid encased metals are converted into liquids for easier elimination.
  • This process of conversion of TMG to Methionine also helps protect the mitochondria, hence there is an energy boost in CFS patients who consume TMG.  

How it works?

  • When TMG gives up a methyl group, it leaves a compound called dimethylglycine.  Dimethylglycine is considered a B-complex vitamin and has been shown to assist with speech and behavior in autistic children and adults, attention deficit-hyperactivity disorder (ADHD), to improve neurological function, and to reduce seizure activity.  It can help one handle stress, improves oxygen utilization, enhances liver activity and helps optimize athletic performance.
  • DMG also has anti-inflammatory and anti-aging effects.  Dimethylglycine is used to improve the immune response, to shrink tumors, and to enhance anti-viral, anti-bacterial, and anti-tumor defenses.  It has also been shown to benefit chronic fatigue syndrome, allergies, respiratory disorders, alcoholism, and drug addiction.