Key Studies on Sulforaphane (Broccoli Sprouts Extract)
- Sulforaphane (SFN), a natural compound derived from broccoli/broccoli sprouts, has been demonstrated to be used as an anti-tumor agent in different types of cancers.
- SFN inhibited thyroid cancer cell growth by promoting mitochondrial-mediated apoptosis. (R1)
- When children with Autism Spectrum Disorder (ASD) were treated with Sulforaphane from broccoli, their urinary metabolites correlated with changes in symptoms, and they clustered into pathways of oxidative stress, amino acid/gut microbiome, neurotransmitters, hormones, and sphingomyelin metabolism. (R2) These results suggest that Sulforaphane played a role in reducing the symptoms of ASD via these pathways.
- Another study highlighted the neuroprotective nature of Sulforaphane, wherein daily injections of sulforaphane increased the threshold of seizures to 6Hz and protected mice against pilocarpine-induced status epilepticus (SE).
- The study also showed that sulforaphane introduced a difference in antioxidant levels between the hippocampal formations and blood plasma. Sulforaphane treatment further reduced the extent of hippocampal lipid peroxidation and protected hippocampal mitochondria. (R3)
- R1. Wang, L.; Tian, Z.; Yang, Q.; Li, H.; Guan, H.; Shi, B.; Hou, P.; Ji, M., Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway. Oncotarget 2015, 6 (28), 25917-31.
- R2. Bent, S.; Lawton, B.; Warren, T.; Widjaja, F.; Dang, K.; Fahey, J. W.; Cornblatt, B.; Kinchen, J. M.; Delucchi, K.; Hendren, R. L., Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Molecular autism 2018, 9, 35.
- R3. Carrasco-Pozo, C.; Tan, K. N.; Borges, K., Sulforaphane is anticonvulsant and improves mitochondrial function. J Neurochem 2015, 135 (5), 932-42.