Suspect you may be carrying MTHFR Mutated Genes? You SHOULD!
Especially if you’re feeling low energy with symptoms of anxiety and depression! Read this to discover about UNDERMETHYLATION & what to do about it?
How Common is MTHFR Genetic Mutations
1 in 2 or up to 50% of all people experience from this MTHFR Gene defects, inherited from parent to child.
What’s MTHFR mutation
MTHFR actuallys stands for Methylenetetrahydrofolate Reductase, a type of enzyme to turn folic acid into methylfolate (aka usable form of folate) which is used constantly in each “methylation cycle”.
MTHFR Gene Mutations affect our body’s ability to convert folic acid into folate, impacting the body’s ability to carry out methylation function effectively.
MTHFR and Methylation Functions
Methylation is a process by which methyl groups are either removed (“de-methylation”) or added (“re-methylation”) from other molecules, transforming these methyl groups into various compounds. Note: a Methyl group is made of 1 carbon & 3 hydrogen molecules.
Methylation regulates gene expression, activates MTHFR genes on & off through different metabolic processes. Methylation occurs at a rate of 12 million times per second.
This influences your enzymes, hormones, and neurotransmitters, and so many things!
Table: Basics of Methylation Cycle
|Methylation Cycles Processes||Crucial For|
|Make new cells (e.g. red blood cells)||Recovery. Every single organs of our body regenerates new cells all the time|
Serotonin, dopamine or norepinephrine
|Brain health: healthy neurotransmitter activity is responsible for emotional stability.
Psychological & psychiatric wellbeing.
|Histamine pathway||Nutrients conversion & distribution and bioavailability.
Regulating histamine load, bodily response’s to allergies
|Homocysteine to Methionine Amino acid||Healthy heart function : keeping cholesterol levels balanced so it doesn’t clog up our arteries & organs. This is important to maintain low level of LDL/ Bad cholesterol, preventing fatty liver disease, high blood pressure, etc.|
|Mitochondrial function||Critical for cellular energy production/|
|Detoxification||Help the body to detoxify heavy metals and toxins|
|SAM / S-adenosylmethionine||Homocysteine comes together with folate and methyl-B12 to make something called SAM or S-adenosylmethionine (in supplements, it is called SAMe). Without enough SAM, our metabolic processes, including detoxification in the liver, breakdown of adrenaline, and energy production in the mitochondria, come to a standstill.|
|Nitric oxide||Exercise & physical performance|
|Immune system||he nervous system communicates with immune cells, so a faulty methylation process can lead to immune imbalances, which can turn a simple cold or flu into pneumonia or and auto-immune disease.|
Methylation cycles impact pretty much every single biological processes in our body. Our systems are interconnected.
When you don’t have enough methyl group, you will be undermethylating. When you have too much methyl groups, you will be overmethylating.
Undermethylation and Overmethylation influence our physical & mental health quite significantly!
Mthfr Mutation Symptoms – UNDERMETHYLATION vs OVERMETHYLATION vs NORMAL METHYLATION
Do you identify with this list of MTHFR mutation symptoms?
Cognitive decline symptoms (e.g. poor concentration, brain fog)
Susceptible to anxiety & depression due to abnormally low serotonin
Women – fertility problems, painful menstrual cycles, period moodswing,, fibromyalgia, ovarian issues
Low pain tolerance
|Highly activated neurotransmitters, so often think outside of the box
Difficulty slowing down
When experiencing depression, this can be life-consuming. These individuals are more susceptible to suicidal thoughts, behaviors.
High pain tolerance
|Characteristics||Competitive, ambitious, driven & passionate to succeed, control freak
E.g. doctors, teachers, sales people or other high-pressure type roles
|Creative – artists, musicians, poets, actors|
Typical Nutrients Deficiencies for Undermethylators vs Overmethylators
|High histamine||Low histamine|
|Low zinc||High zinc|
|Low copper||High copper|
|High basophil count||Low basophil count|
|High homocysteine level||Low homocysteine level|
|High heavy metals||Low heavy metals|
Undermethylation is a Big Problem
Prolonged undermethylation can lead to severe health symptoms.
When you’re an undermethylator, inadequate conversion of folic acid strips methyl group at the DNA level. DNA is where all the instructions are made to your genes.
Undermethylation has already been linked to these health problems:
- Autoimmune disorders
Researchers & Scientists are increasingly studying the links between MTHFR-mutated genes to various health concerns and medical conditions.
So much is going on this field, Which is highly exciting! Hopefully, we will learn more in the not too distant of future.
When this happens, our medical doctors are becoming more educated on the topic, and able to transition to more holistic health care practise rather than viewing the symptoms in isolation.
Currently, diagnosis of anxiety & depression is highly premature, and to prescribe antidepressants in actually premature & dangerous!
Severity Varies for the Different MTHFR Mutation
The most commonly studied MTHFR genes mutation are: c677t & a1298c alleles.
Since we inherit 2 allele copies of MTHFR genes (1 gene SNP from our mom + 1 gene SNP from our dad).
Table: Homozygous, Heterozygous and Compound Heterozygous MTHFR Mutated Genes
|MTHFR c677t SNP||MTHFR a1298c SNP||MTHFR Mutated Genes||Loss of Methylation Function|
|1 copy||1 copy||Compound Heterozygous||-50%|
MTHFR Symptoms List
MTHFR Symptoms include:
|Impact||Illness/ Manifestation||Common Symptoms|
|Brain||Anxiety and Depression||Cognitive decline (brain fog)
Low mood, Low motivation, Low levels of serotonin
Lack of interest in sex
Problems with sleep (chronic insomnia)
Attention deficit problem (ADHD)
|Gut Health||Irritable Bowel Syndrome (“Leaky Gut Syndrome”)||Issues with digestive health/ symptoms of irritable bowel syndrome
Poor nutrients absorption
Struggle to keep inflammation levels under control (allergies to foods ingredients, chemicals, preservatives)
Recurring yeast infection/ candida
|Endocrine / Hormone production||Chronic Fatigue Syndrome & Fibromyalgia||Inability to deal with stress
Thyroid disorders (especially hypothyroid)
|Liver||Oxidative Stress / Immune system issues such as Autoimmune condition||Detoxification
Eliminate Toxins & Heavy metals
Chronic Pain disorders
|Heart / Cardiovascular||High Cholesterol||High/ Elevated homocystine levels|
Ask Your Naturopathic / Integrative Medicine Doctor About MTHFR
- Mayo clinic
- Naturopathic doctor (with a doctorate degree from a federally-accredited program) Doctors near you
If you suspect you may be suffering from MTHFR genetic defect, speak to your medical doctor who will be able to organize some testing for yo. There is a good chance that your insurance won’t cover MTHFR gene testing – this can cause an arm & a leg.
MTHFR Mutation Blood Test & Diagnosis
- Gene genie
- Cheapest option: order a Simple Blood Histamine Test
- Not a fool-proof test but it’s probably a cheap option if you just want to confirm UNDER-METHYLATION VS OVER-METHYLATION. Ask your doctor to interpret the results.
- There’s an indirect relationship between histamine and methylation. So we see individuals who are, for example, high in histamine. they tend to be low in methyl. And when they are high in methyl, they tend to be low in histamine. So we can actually measure indirectly concentrations of methyl.
How to treat Undermethylation: Watch out for Toxic Negative Effects of Pharmaceutical Medication
Undermethylators often don’t do well when taking pharmaceutical medications due to limited detoxing capability.
Watch out especially when you’re taking these commonly prescribed medications:
- Birth Control Pills
- Birth control pills are synthetic estrogens to regulate your hormone & menstrual cycles. The byproduct of these pills must be processed. If you have a C677T MTHFR mutation, you are less able to eliminate this out of your symptoms.
- Anti-depressant pills
- Negative side-effects, which are mostly depression or even suicidal or homicidal behaviors.
- Anti-anxiety medication
So what is can you do to treat undermethylation? Our recommendation is to take a targeted nutritional approach/ nutrients therapy. But the answer is not as simple as: taking copper. In fact, there are dangers of copper toxicity and taking copper supplement can actually do more harm than good. Discover how Fatigue No More can support you in your healing journey.